All Publications
Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis
Cramer Z, Wang Z, Leu NA, Monaghan K, Rhoades JH, Tian Y, Rico J, Mendez D, Petroni R, Kim MS, Matsuda R, Carrera MF, Brodsky IE, Li N, Lengner CJ, Blanco MA (2025). Manuscript in press, PNAS
An epigenetic-signaling pathway interplay re-wires transcriptional program to induce therapeutic differentiation of AML
Hosseini A, Dhall A, Ikonen N, Sikora N, Amara ML, Jiao A, Sergeev P, Zee BM, Kawabata KC, Melnick A, Vyas P, Ren B, Heckman CA*, Blanco A*, and Shi Y* (2025). Nature 642, 508–518
*Co-corresponding authors
CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cells development
Hwang YS, Blanco MA*, Sasaki K* (2023). PLoS Genetics. Dec 13;19(12) *co-corresponding author
Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors
Zhang H, Yu P, Tomar VS, Atherton MJ, Lu Z, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George S, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY (2022). Nature Cancer, 3(7):808-820
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
Guo Y; Ji F; Murn J; Frankhouser D; Blanco A; Chiem C; Jang M; Sadreyev R; Rockne R; Sykes D; Hochedlinger K; Sihem Cheloufi (2022). Nature Communications, 13(1):2350.
KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene expression programs
Yan F*, Li J*, Milosevic J*, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB**, Blanco MA** (2021). Cancer Discovery. Online ahead of print, December 1, 2021 CD-20-1459.
*co-first authors **co-corresponding authors
Chromatin-state barriers enforce an irreversible mammalian cell fate decision
Blanco MA*±#, Sykes DB±, Gu L±, Wu M, Cheloufi S, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Meissner A, Hoechedlinger K, Scadden DT*, Shi Y* (2021). Cell Reports, 37(5)
*Co-corresponding authors ±co-first authors #Lead contact
Combined epigenetic and metabolic treatments overcome differentiation blockade in AML
Zee BM, Poels KE, Yao C, Jacobus WD, Senior E, Jambhekar A, Lovitch SB, Dhall A, Ma J, Endress JE, Harris IS, Blanco MA, Haigis MC, Michor F, Licht JD, Shi Y (2021). iScience, 25;24(6):10265
Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κβ survival pathway
Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias J, Siebel C, Blanco MA, Klein-Szanto A, Lengner C, Welm AL, Kang Y, and Rumela Chakrabarti (2021). Nature Communications, Jan 18;12(1).
The Hedgehog pathway suppresses CD4 T cell driven neuroinflammation
Benallegue N, Kapoor R, Kebir H, Crockett A, Cheslow L, Abdel-Hakeem MS, Gesualdi J, Miller MC, Wherry J, Church M, Blanco MA, Alvarez JI (2021). Brain, 144(6):1670-1683
Epigenetic and transcriptional control of the epidermal growth factor receptor (EGFR) regulates the tumor immune microenvironment in pancreatic cancer
Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ (2021). Cancer Discovery, 11(3):736-753.
Loss of ELF5/FBXW7 stabilizes IFNGR1 promoting growth and metastasis of triple negative breast cancer through interferon-γ signaling
Singh S, Kumar S, Srivastava R, Murali H, Kim S, Tobias J, Blanco A, Saffie R, Zaidi M, Sinha S, Fuchs S, Busino L, Chakrabarti R (2020). Nature Cell Biology, 22(5):591-602.
Tumor cell-intrinsic USP22 suppresses antitumor immunity in pancreatic cancer
Li J, Yuan S, Norgard RJ, Yan F, Yamazoe T, Blanco A, Stanger BZ (2020). Cancer Immunol Res, 8(3):282-291
Re-programming chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG
Anastas Jn, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y (2019). Cancer Cell, 11;36(5):528-544.
Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
Celia-Terrasa T, Bastian C, Liu D, Ell B, Aillo NM, Wei Y, Zamalloa J, Blanco MA, Hang X, Kunisky D, Li W, Williams ED, Rabitz H, Kang Y (2018). Nature Communications, 9(1):5005.
ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer
Kumar S, Wilkes DW, Samuel N, Blanco MA, Nayak A, Alicea-Torres K, Gluck C, Sinha S, Gabrilovich D, Chakrabarti R (2018). Journal of Clinical Investigation, 128 (11): 5095-5109.