All Publications

KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene expression programs

Yan F*, Li J*, Milosevic J*, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB**, Blanco MA** (2021). Cancer Discovery. Online ahead of print, December 1, 2021 CD-20-1459.

*co-first authors **co-corresponding authors

Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Blanco MA*±#, Sykes DB±, Gu L±, Wu M, Cheloufi S, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Meissner A, Hoechedlinger K, Scadden DT*, Shi Y* (2021). Cell Reports, 37(5)

*Co-corresponding authors ±co-first authors #Lead contact


Combined epigenetic and metabolic treatments overcome differentiation blockade in AML

Zee BM, Poels KE, Yao C, Jacobus WD, Senior E, Jambhekar A, Lovitch SB, Dhall A, Ma J, Endress JE, Harris IS, Blanco MA, Haigis MC, Michor F, Licht JD, Shi Y (2021). iScience, 25;24(6):102651


Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κβ survival pathway

Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias J, Siebel C, Blanco MA, Klein-Szanto A, Lengner C, Welm AL, Kang Y, and Rumela Chakrabarti (2021). Nature Communications, Jan 18;12(1).


The Hedgehog pathway suppresses CD4 T cell driven neuroinflammation

Benallegue N, Kapoor R, Kebir H, Crockett A, Cheslow L, Abdel-Hakeem MS, Gesualdi J, Miller MC, Wherry J, Church M, Blanco MA, Alvarez JI (2021). Brain, 144(6):1670-1683


Epigenetic and transcriptional control of the epidermal growth factor receptor (EGFR) regulates the tumor immune microenvironment in pancreatic cancer

Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ (2021). Cancer Discovery, 11(3):736-753.


Loss of ELF5/FBXW7 stabilizes IFNGR1 promoting growth and metastasis of triple negative breast cancer through interferon-γ signaling

Singh S, Kumar S, Srivastava R, Murali H, Kim S, Tobias J, Blanco A, Saffie R, Zaidi M, Sinha S, Fuchs S, Busino L, Chakrabarti R (2020). Nature Cell Biology, 22(5):591-602.


Tumor cell-intrinsic USP22 suppresses antitumor immunity in pancreatic cancer

Li J, Yuan S, Norgard RJ, Yan F, Yamazoe T, Blanco A, Stanger BZ (2020). Cancer Immunol Res, 8(3):282-291


Re-programming chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG

Anastas Jn, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y (2019). Cancer Cell, 11;36(5):528-544.


Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

Celia-Terrasa T, Bastian C, Liu D, Ell B, Aillo NM, Wei Y, Zamalloa J, Blanco MA, Hang X, Kunisky D, Li W, Williams ED, Rabitz H, Kang Y (2018). Nature Communications, 9(1):5005.


ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer

Kumar S, Wilkes DW, Samuel N, Blanco MA, Nayak A, Alicea-Torres K, Gluck C, Sinha S, Gabrilovich D, Chakrabarti R (2018). Journal of Clinical Investigation, 128 (11): 5095-5109.

N6-Methyldeoxyadenosine: a new epigenetics mark in eukaryotes?

Luo, G-Z, Blanco MA, Greer EL, He C, Shi Y (2015).  Nature Reviews Molecular Biology, 16 (705-710).

 

DNA methylation on N(6)-Adenine in C. elegans (2015).

Greer EL*, Blanco MA*, Sendinc E, Aristizábal-Corrales D, Liu J, Gu L, Aravind L, He C, ShiY (2015).  Cell, 161(4): 868-78. (Cover article). *Denotes equal contribution

 

The histone chaperone CAF-1 safeguards somatic cell identity during transcription factor-induced reprogramming (2015).

Cheloufi S, Elling U, Hopfgartner B, Jung Y, Murn J, Badeaux A, Blanco A, Ang CE, Tennen D, Ferrari F, Wesche D, Abazova N, Hogue M, Tasdemir N, Rathert P, Vidal S, Fellner M, Wenzel D, Zinner M, Stadtfeld M, Almouzni G, Lowe SW, Rinn J, Wernig M, Shi Y, Park P, Penninger JM, Zuber J, Hochedlinger K (2015).  Nature, 528 (75281):218-24.

 

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.

Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco MA, Chen S, Stutzer A, Armache KJ, Simon MD, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y (2014).  Cell, 157(4):869-81.

 

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis .

Zheng H, Shen M, Zha YL, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang HY, Kang Y (2014).  Cancer Cell 26(3):358-73.

 

MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.

Wan L, Lu X, Yuan S, Wei Y, Guo F, Shen M, Yuan M, Chakrabarti R, Hua Y, Smith HA, Blanco MA, Chekmareva M, Wu H, Bronson RT, Haffty BG, Xing Y, Kang Y (2014).  Cancer Cell 26(1): 92-105.

 

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.

Chakrabarti R, Wei Y, Hwang J, Hang X, Blanco MA, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S, Kang Y (2014).  Nature Cell Biology 16(10):1004-15.

 

A quantitative atlas of histone modification signatures from human cancer cells.

LeRoy G, DiMaggio PA, Chan E, Zee BM, Blanco MA, Bryant B, Flaniken IZ, Liu S, Kang Y, Trojier P, Garcia BA (2013). Epigenetics Chromatin 6(1).

 

Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.

Chakrabarti R, Hwang J*, Blanco MA*, Wei Y, Lukačišin M, Romano RA, Smalley K, Liu S, Yang Q, Ibrahim T, Mercatali L, Amadori D, Haffty BG, Sinha S, Kang Y (2012).  Nature Cell Biology 14(11): 1212-22. *Denotes equal contribution

 

Global secretome analysis identifies novel mediators of bone metastasis.

Blanco MA, LeRoy G, Khan Z, Alečković M, Zee B, Garcia BA, Kang Y (2012).  Cell Research 22(9): 1339-55. (Cover Article)

 

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins.

Leroy G, Chepelev I, Dimaggio PA, Blanco MA, Zee BM, Zhao K, Garcia BA (2012).  Genome Biology 13(8): R68.

 

Identification of Staphylococcal nuclease domain containing 1 (SND1) as a Metadherin-interacting protein with metastasis- promoting functions.

Blanco MA, Aleckovic M, Hua Y, Xu Z, Wei Y, Kang Y (2011).  J Biol Chem, 286(22): 19982-92.

 

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.

Korpal M, Ell BJ, Buffa FM, Khan Z, Blanco MA, Hua Y, Hu G, Garcia BA, Singh M, Harris AL, Kang Y (2011).  Nature Medicine, 17(9): 1101-8.

 

Signaling pathways in breast cancer metastasis — novel insights from functional genomics.

Blanco MA and Kang Y (2011).  Breast Cancer Research, 13(2): 206-214.

 

Genomic gain of 8q22 activates metadherin and promotes chemoresistant metastasis of poor-prognosis breast cancer.

Hu G, Yang Q, Chong RA, Wei Y, Blanco MA, Li F, Haffty B, Reiss M, Kang Y (2009).  Cancer Cell, 15(1): 9-20. (Cover Article)

 

Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes.

Wang Q, A Turlington, S Heo, A Blanco, J Tian, Z Xie, BF Yan, YS Wan (2005). Int J Mol Med 15 (4), 633-640.

 

Maximum longevities of chemically protected and non- protected fishes, reptiles, and amphibians support evolutionary hypotheses of aging.

Blanco, MA and Sherman, P.W. (2005).  Mech Ageing Dev 126, 794-80.